14-3-3 Proteins in Lewy Bodies in Parkinson Disease and Diffuse Lewy Body Disease Brains
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چکیده
منابع مشابه
14-3-3 proteins in Lewy bodies in Parkinson disease and diffuse Lewy body disease brains.
Several components of Lewy bodies have been identified, but the precise mechanism responsible for the formation of Lewy bodies remains undetermined. The 14-3-3 protein family is involved in numerous signal transduction pathways and interacts with alpha-synuclein, which is a major constituent of Lewy bodies. To elucidate the role of 14-3-3 proteins in neuro-degenerative disorders associated with...
متن کامل[Diffuse Lewy body disease].
Diffuse Lewy body disease (DLBD) has been studied from various viewpoints and, although clinical diagnostic criteria for DLBD have been proposed, diagnosis remains difficult. DLBD has been reported to be the second most common form of dementia in the aged, following Alzheimer-type dementia. It has, however, been clinically under-diagnosed. Therefore, the search for diagnostic markers for DLBD m...
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In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type. Later, we added the cerebral type. As we have propo...
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alpha-Synuclein is the major constituent of Lewy bodies and Lewy neurites in Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Relatively little is known about the exact mechanism of alpha-synuclein deposition and fibrillization in these alpha-synucleinopathies. In order to better understand the pathogenesis of alpha-synucleinopathies it is important to identify molecules that regul...
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Objectives: Electroencephalography can still reveal a variety of focal abnormalities in different neurological diseases. EEG could represent an easy and economical tool to differentiate parkinsonisms when compare to neuroradiological studies. We want to report the EEG findings in a serie of diffuse lewy body disease and demented Parkinson ́s disease patients of our unit of movement disorders, in...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2002
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/61.3.245